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Pharmacy / Antidepressants / Bupropion (Wellbutrin)
Bupropion (Generic Wellbutrin)

Dosage: 150 mg

Price: starts from $0.80 per pill

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Bupropion (Wellbutrin)

The principle of action of the antidepressant Bupropion (Wellbutrin) is to inhibit the reuptake of dopamine and norepinephrine selectively.

In this case, there is a slight inhibition of serotonin reuptake.

The active substance is an implacable opponent of nicotine, so it is used as an antagonist of nicotinic choline receptors.

Indications for use

The pharmacological product is used in the treatment of depression and nicotine addiction.

If, after a treatment course, an adequate result is achieved, the drug is prescribed to prevent exacerbations and relapses of depression.

The active substance provides a high therapeutic effect for the following problems:

  • attention deficit disorder;
  • anxiety;
  • obesity;
  • hyperactivity;
  • seasonal disorders;
  • violations in the sexual sphere;
  • neuropathic pain.

Wellbutrinis included in the complex therapy of Crohn’s disease and psoriasis. The drug helps reduce the inflammatory mediator tumor factor-alpha.

Instructions for use

Before you start taking Bupropion, you need to read the instructions from the annotation carefully.

The product has a prolonged effect.

It should be consumed whole and washed down with pure water.

You should not chew the tablets, as this leads to an increased risk of side effects.

Treatment regimen using the drug:

  • you need to start with a dose of 150 mg;
  • number of doses per day – once (in the morning);
  • in the absence of a therapeutic response, the daily dose increases to 300 mg;
  • the maximum daily dose recommended in rare cases is 450 mg;
  • The duration of the course is determined individually (from several months to a year).

If it is necessary to increase the daily dose, the following restrictions are observed: the dose is changed by no more than 100 mg for 3 days.

Pregnancy, lactation period

The pharmacological agent has not undergone clinical trials in humans.

Lack of information and lack of research data is the basis for limiting its use during pregnancy and lactation due to the potential risk to the fetus (infant).

Bupropion is used during a sensitive period for a woman in exceptional cases when the threats outweigh the risks.

If therapy coincides with the lactation period, breastfeeding is artificially interrupted.

Side effects

Manufacturers warn in the annotation that Wellbutrin(Bupropion) can provoke a negative reaction in the body, especially if you are allergic to the active substance.

This manifests itself in the following symptoms:

  • angioedema;
  • hives;
  • bronchospasm (shortness of breath);
  • myalgia;
  • arthralgia;
  • anaphylactic shock.

Long-term therapy with Bupropion affects the metabolic functions of the body. During this period, the patient experiences weight loss (even to the point of anorexia), and the concentration of glucose in the blood changes.

Changes also occur in the psycho-emotional background, which is facilitated by:

  • insomnia;
  • unreasonable irritability;
  • hallucinations;
  • aggressive behavior, etc.

The official instructions provide a wide list of side effects caused by the active substance of the product being described. Effects are observed in the central nervous system, cardiovascular system, visual apparatus, etc.

To avoid an unwanted reaction, you need to read the possible problems carefully and strictly follow the treatment regimen recommended by your doctor.

This is especially true for the daily dosage and duration of treatment.

Restrictions on use

Like any pharmacological agent, Bupropion has a number of contraindications for use.

They must be taken into account when selecting medications for therapy.

The restrictions apply to the following cases:

  • allergy to bupropion hydrochloride;
  • convulsions;
  • stopping taking sedatives (alcohol);
  • use of other bupropion-containing drugs;
  • bulimia (anorexia due to nervousness);
  • use of drugs with monoamine oxidase inhibitors.

You can start taking an antidepressant no earlier than 2 weeks after you stop using irreversible monoamine oxidase inhibitors.

A direct contraindication is considered to be age under 18 years.

Patients with problems with the kidneys, liver, and cardiovascular system should first consult with a doctor about the safety of using the medicine.


When including Bupropion in complex therapy, its compatibility with other pharmacological products is taken into account.

Its simultaneous use with certain medications is prohibited.

Among them:

  • anxiliotics;
  • other antidepressants;
  • glucosteroids;
  • antibiotics of some types (Ciprofloxacin);
  • insulin and sugar-lowering medications;
  • drugs for the treatment of Parkinson’s disease;
  • beta blockers.

Precautionary measures

One of the common adverse reactions is sleep disturbance.

To eliminate the problem, the attending physician recommends reducing the daily dose of Bupropion or increasing the time between doses of the medication. Based on this, you should strictly adhere to the 24-hour interval.

Many antidepressants have a negative effect on sexual function. The likelihood of such a side effect with Bupropion is close to zero (according to statistics).

With long-term use, the drug in question does not cause weight gain. However, a different scheme is proposed for losing weight than for the purpose of restoring the psycho-emotional background. It is determined by the doctor taking into account the characteristics of the body.

During the period of therapy, you should not drive vehicles or other mechanisms that pose a danger to the patient himself or others. The active substance can inhibit motor function and affect psychomotor function.